NBC TODAY Show

2:44 -- Nov. 21: Closing arguments are underway in the Italian murder trial of American college student Amanda Knox. NBC’s Michelle Kosinski reports from Perugia with the latest.

3:42 -- Nov. 21: David Zinczenko of Men’s Health magazine joins NBC’s Lester Holt with some simple swaps that’ll let you enjoy Thanksgiving, without piling on unnecessary calories

4:24 -- Nov. 21: Will Senate Majority Leader Harry Reid muster enough votes to bring the Democrats’ health legislation to the floor for debate? Sens. Judd Gregg, R-N.H., and Ben Cardin, D-Md., join NBC’s Lester Holt to discuss.

5:42 -- Nov. 21: After just one full day in theatres, the second installment in the “Twilight” series is already breaking records.

1:54 -- Nov. 21: Captured nearly one month ago, Paul and Rachel Chandler are seen pleading for their lives in a videotape obtained by a British television station. NBC’s Stephanie Gosk reports

3:15 -- Nov. 21: Best-selling author John Grisham sits down with NBC’s Amy Robach to discuss his latest book, “Ford County.”

2:08 -- Nov. 21: In front of a captivated studio audience, the queen of daytime television announced that next season will be her program’s final, after 25 years on air. NBC’s Kevin Tibbles reports.

3:06 -- Nov. 21: This year along, some 20,000 species will become extinct. NBC’s Amy Robach sits down with Jeff Corwin, whose documentary, “100 Heartbeats” highlights species pushed to the brink of extermination, as well as some encouraging signs of hope.